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Lentiviral particles were produced by co-transfecting HEK293T cells with the respective transfer vectors, the packaging plasmids psPAX2 (#PE081, Geneppl technology) and the envelope plasmid pMD2.G (#PE082, Geneppl technology) using Lipofectamine 3000 Transfection Reagent (#L3000001, Thermo Fisher Scientific)