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For lyophilized powder at room temperature, the timeline is more forgiving than you might expect

A foul, sour, or unusual smell indicates bacterial contamination, which can develop when preservatives break down at elevated temperatures

The recommended dose of Pemetrexed when administered with Cisplatin : for initial treatment of locally advanced or metastatic non-squamous NSCLC in patients with a creatinine clearance (calculated by Cockcroft-Gault equation) of 45 mL/min or greater is 500 mg/m2 as an intravenous infusion over 10 minutes administered prior to Cisplatin on Day 1 of each 21-day cycle for up to six cycles in the absence of disease progression or unacceptable toxicity

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[DOI] [PubMed] [Google Scholar] 84.Forslund C., Aspenberg P