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Finally, 3-ketoacyl-CoA is split at the 2,3-position by thiolase (3-ketoacyl-CoA-thiolase), forming acetyl-CoA and a new acyl-CoA two carbons shorter than the original acyl-CoA molecule

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When acting on the melanocortin 1 receptor (MC1R), melanotan stimulates melanin production and tyrosinase activity, leading to melanocyte proliferation and skin hyperpigmentation (Figure 3)

For instance, Legionella forms a replicative vacuole that avoids lysosomal fusion and instead recruits ER-derived membranes through the action of type IV secretion system effectors (Ham et al., 2011