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Laboratory models show TB-500 activates HIF-1 pathways under hypoxic conditions

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Further studies demonstrated that Sinomenine exerted its core anti-tumor effect through inhibition of the PI3K-AKT-mTOR signaling pathway, manifested by downregulation of p-PI3K/PI3K, p-AKT/AKT, and mTOR expression, reduced AKT membrane translocation, and consequent suppression of pathway activity (255)

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