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It can be divided into four different subfamilies: caspase recruitment domain (CARD), death domain (DD), death effector domain (DED), and the pyrin domain (PYD) 40

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GO-4 has the following primary mechanism of action: Melphalan cross-links cancer cell DNA, which kills the cancer cell if the cross-link is not repaired

Myocardial oxygen consumption was calculated according to Neely (Neely et al., 1967) considering coronary flow and heart dry weight, which averaged 0.212 g in adults and 0.237 g in old animals