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Protein binding has little effect on the clearance of high-extraction drugs, as the liver's high metabolic capacity can efficiently remove the drug from binding proteins as it passes through

COVID-19 is a viral infectious disease caused by a new-to-us coronavirus

Increases in genes associated with cytokine pathways, antigen presentation, the complement cascade, and reactivity [e.g., glial fibrillary acidic protein ( Gfap )] were observed in astrocytes in the hippocampus, hypothalamus, visual cortex, striatum and cerebellum of aged mice (24-months-old

de Mendona ELSS, Fragoso MBT, de Oliveira JM, et al

PLoS ONE 12(10):e0186615