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The results showed a decrease in immobility time, increased withdrawal latency and paw threshold, and normalization of monoamine and monoamine derivative levels 94

Looking ahead, the field needs to focus on developing smart, multi-purpose nanocarriers that can deliver drugs, enable imaging, and even tweak immune responses all in physiologically relevant models and under strict quality control

We revealed, that despite many attempts, which have been made to develop transporter-utilizing (pro)drugs and nanocarriers for brain delivery of different drugs, there are several factors limiting the rational development and successful application of the approach to humans