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It is precisely because the liver questions are the hardest and slowest to answer that the FDAs Breakthrough Therapy designation in this indication is meaningful for the development timeline, even though it changes nothing about the drugs current unapproved status

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A: Docking of the GSTP1 monomer (from chain A of PDB entry 1AQW, represented as a protein surface) and the HPV-16 E7 CR3 dimer (modeled in this study and represented as a protein backbone with the two subunits distinguished by green and orange colors)

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