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Abbreviations ABS: Abnormal behavior checklist ADI: Acceptable daily intake ADOS- 2: Autism diagnostic observation schedule AGEs: Glycation end products ASD: Autism spectrum disorder ATEC: Autism treatment evaluation test ATP: Adenosine triphosphate BHA: Butylated hydroxyanisole BHT: Butylated hydroxytoluene CARS- 2: Childhood autism rating scale dACC: Dorsal anterior cingulate cortex DHA: Docosahexaenoic acid DSM- 5: Diagnostic and Statistical Manual of Mental Disorders fifth edition EPA: Eicosapentaenoic acid FODMAP: Fermented soluble oligosaccharides disaccharides monosaccharides and polyols GABA: Gamma aminobutyric acid GARS- 2: Gilliam autism rating scale GFCF: Gluten-free-casein-free GSH: Glutathione GSH-Px: Glutathione peroxidase HDAC2: Histone deacetylase 2 IQ: Intelligence quotient IL- 6: Interleukin-6 IL- 1: Interleukin-1 lgG: Immunoglobulin G MCT: Medium chain triglyceride MMP- 9: Matrix metalloproteinases NAA: N-acetylaspartate PFC: Prefrontal cortex PUFA: Polyunsaturated fatty acids ROS: Reactive oxygen species SRS: Social sensitivity scale TBHQ: Tert-butylhydroquinone tCr: Total creatine tNAA: Total N-acetylaspartate TNF-: Tumor necrosis factor- UVB: Ultraviolet B VDR: Vitamin D receptor 18 FDG PET: 18 Fluoro-deoxyglucos References Hirota T, King BH

Kuro-oMMatsumuraYAizawaHKawaguchiHSugaTUtsugiTet alMutation of the mouse klotho gene leads to a syndrome resembling ageing