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For a comprehensive summary of these trial results and Phase 3 updates, see our retatrutide clinical trials 2026 update

Have a B12-rich food like steak, and your serum level can rise to more than 1500 pg/mL for a short time

Combine low intake with impaired absorption, and deficiency becomes highly probable without supplementation

Furthermore, additional testing within the same cohort may have induced type I error inflation and was not corrected for

The endocrinologist or prescribing physician manages the indication for treatment, dose escalation, metabolic response, systemic side effects and long-term safety