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Increasing the capacity of the TCA cycle improves the energetic status of the cell and in order for neurons to benefit from anaplerosis, glutamine derived from TCA cycle intermediates are transferred from astrocytes to neurons where they are re-converted to intermediates, thereby increasing the capacity of the TCA cycle to produce energy [19]

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Knockdown and overexpression of GPX3 in human prostate cells GPX3-target specific small interfering RNA (siRNA) was synthesized by Genepharma Ltd

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