Engineered microbial nanohybrids for tumor-mediated NIR II photothermal enhanced ferroptosis/cuproptosis and immunotherapy
625 RNAi-mediated screening revealed that ALOX5 is the primary factor required for ACSL4-independent ferroptosis induced by mutant huntingtin protein HTTQ94
2.6 P53 The p53 protein serves a critical role in the cellular response to iron overload, maintaining a balanced state of iron by finely regulating the transcriptional activity of specific genes ( Moreover, p53 is not only involved in iron homeostasis regulation but also enhances the cellular antioxidant defense system by activating the expression of a series of antioxidant enzymes, including GSTs, HO-1, and superoxide dismutase (SOD) ( When the skin is exposed to harmful environmental factors, such as ultraviolet rays, the p53 protein promptly activates its protective mechanism ( Moreover, p53 plays a pivotal role in combating skin aging
There is a bidirectional link between the two phenomena: an increase in permeability promotes dysbacteriosis ( + (CD4 + ) T-cell expansion and interleukin 17A production that limits enteric pathogen invasion ( Salmonella typhimurium infection is more severe in transgenic mice with increased intestinal permeability, suggesting that barrier defects ultimately result in enhanced disease progression despite the activation of protective mucosal immunity ( Intestinal mucus is a critical component of the IEB since it forms a direct link between the host and the microbiota
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