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Visual and olfactory signs of degradation including re-cloudification after clear dissolution, yellow tint, and sulfur smell are legitimate indicators to discard a vial, not rinse and retry

Ferroptosis, an oxidative stress-dependent regulated cell death modality, is potently triggered by oxidative stress, a mechanism particularly critical in ocular pathologies (159).Accumulating evidence implicates ferroptosis in retinal neurodegeneration and DR pathogenesis, supporting oxidative stress as a central bridge linking ferroptosis to DR progression (160, 161)

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This review provides a comprehensive analysis of ferroptosis, focusing on its molecular underpinnings, regulatory networks, and opportunities for therapeutic modulation

Life Sci 284:119911 Sayed AM, Abdel-Fattah MM, Arab HH, Mohamed WR, Hassanein EH (2022) Targeting inflammation and redox aberrations by perindopril attenuates methotrexate-induced intestinal injury in rats: role of TLR4/NF-B and c-Fos/c-Jun pro-inflammatory pathways and PPAR-/SIRT1 cytoprotective signals