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One study in approximately 8,900 adults found that those under the age of 65 with the lowest magnesium intake had a 22% higher risk of developing depression ( Another 12-week study in 23 older adults showed that taking 450 mg of magnesium daily reduced depression symptoms as effectively as an antidepressant drug ( Several studies have linked low blood levels and intakes of vitamin B6 to depression

Complex IV) system for mitochondrial oxidative phosphorylation (OXPHOS) and the copper/zinc superoxide dismutase 1 (Cu/Zn-SOD1) system for antioxidant defense (1,2)

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NMDA receptors are voltage-dependent ligand-gated ion channels that requires simultaneous binding of glutamate and a co-agonist (D-serine or glycine) to open the ion channel

Research in non-HIV populations exists but is limited