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For example, TNF- has been shown to interfere with the signaling required for NMDA receptor activation and promote the internalization of AMPA receptors, further diminishing synaptic strength (Alvarez Cooper et al

It is active in stem cells and germ cells but typically silenced in most somatic cells

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The mitochondria-targeted antioxidant MitoQ ameliorates myocardial ischemiareperfusion injury by enhancing PINK1/Parkin-mediated mitophagy in type 2 diabetic rats