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Some individuals notice improvements, such as increased energy or reduced neuropathy symptoms, within the first one to two weeks

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A Phase 2 trial (Obesity Research, 2004) found 12 weeks of subcutaneous AOD-9604 produced statistically significant abdominal fat reduction versus placebo without altering fasting glucose or insulin levels

Some people report feeling discouraged or defeated by needing to switch, particularly if cost or access barriers forced the change rather than it being their choice