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This occurs through the direct binding of Cu ions to lipoylated components of the tricarboxylic acid cycle during mitochondrial respiration, leading to the aggregation of lipoylated proteins and the subsequent downregulation of Fe-S cluster proteins, which causes toxic stress to the proteins and ultimately leads to cell death

*Correspondence: Noah Isakov, [email protected] Present addresses: Amitha Muraleedharan, Centre dExcellence en Recherche sur les Maladies Orphelines-Fondation Courtois (CERMO-FC) and Biological Sciences Department, Universit du Qubec Montral (UQAM), Montral, QC, Canada

Clin Infect Dis 1997

Several strategies have been explored to tackle this issue, including extended criteria grafts, machine perfusion for organ preservation of initially inferior quality, living donors, and bioprinting ( The success of organ transplantation was intrinsically woven with advances in understanding the immune responses at the molecular and cellular levels

As a recently reviewed subject (Vukojevic et al., 2022), BPC 157 has been shown to reduce brain lesions, trauma-induced brain injury (Tudor et al., 2010), compression-induced spinal cord injury (Perovic et al., 2019), and stroke (Vukojevic et al., 2020)