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Sikiric et al

While oral vitamins are a common way to supplement your diet, they are far less effective than intravenous (IV) micronutrient therapy

These tumors have an immunosuppressive TME comprised of cells including FOXP3 + regulatory T cells, LAMP3 + tolerogenic dendritic cells, CCL18 + M2-like macrophages, RGS5 + cancer-associated fibroblasts, and LGALS1 + microglial cells

This suggests that intranasal administration of vitamin C may be capable of improving mucociliary clearance of inhaled pollutants

Based on a 5-km time improvement of 2.5% or about 30 seconds (SD = 1 minute) with Protandim , and no improvement in the placebo group, about 34 runners in total were needed (Effect size for ANOVA = f = 0.25, which is moderate, statistical power = 80%, two-sided alpha error probability = 5%, two measurements per group, two groups, correlation amongst repeated measures = 0.50, F-test Family, ANOVA repeated measures, within-between interaction, G*Power 3.1.2, Universitt Kiel, Germany)