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During development and progression of atherosclerosis, Nrf2 signaling modulates many physiological and pathophysiological processes, like regulation of lipid homeostasis, CD36 gene expression regulation, foam cell formation, macrophage polarization, immunity regulation (Th2 differentiation and inhibition of pro-inflammatory gene expression through NFB down-regulation), redox regulation and inflammation, improvement of endothelial dysfunction, as well as GSH synthesis and utilization (234245)

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Data were obtained from Human Protein Atlas database ( ( a-b ) or BioGPS database ( ( c )

The final natural source of ALCAR is the diet, with red meats, especially leaner muscle rich cuts being, a particularly high source

GHRP-6s receptor was originally called the growth hormone secretagogue receptor (GHSR), but due to subsequent discoveries, the hormone ghrelin is now considered the receptors natural endogenous ligand and the receptor has been renamed the ghrelin receptor