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Upon encountering DSBs, NHEJ is initiated by the binding of the Ku70/80 heterodimer to the free DNA ends, facilitating the assembly of essential NHEJ components such as DNA-dependent protein kinase catalytic subunit (DNA-PKcs), X-ray repair cross-complementing protein 4 (XRCC4), and DNA ligase IV (LIG4)

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Subcellular localization of FOXO3a as a potential biomarker of response to combined treatment with inhibitors of PI3K and autophagy in PIK3CA-mutant cancer cells