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The concentration of glutathione in the cell is 10mM (BNID 104679, 104704, 111464), making it the second most abundant metabolite in the cell (after glutamate) ensuring that it plays a dominant role as an electron donor in redox control of protein function

The presence of two or more of these clinical features is used as consensus diagnostic criteria for NF1 [1]

So it takes us back in history, but there was a period between World War II and 1970s where there was a lot of motivation in the research community to do these grand randomized controlled trials of nutrition

Plant GSTs consist of three super families (cytosolic, mitochondrial, and microsomal) and can be further divided into distinct classes: tau (U), phi (F), theta (T), zeta (Z), lambda (L), -subunit of the eukaryotic translation elongation factor 1B (EF1B), dehydroascorbate reductase (DHAR), metaxin, tetrachlorohydroquinone dehalogenase (TCHQD), Ure2p, microsomal prostaglandin E synthase type 2 (mPGES-2), hemerythrin (GSTH), iota (GSTI), and glutathionyl-hydroquinone reductases (GHRs) (Csiszr et al., GSTs represent a relatively large ratio of the total soluble proteins in plant cells, e.g., they comprise ~2% of the soluble protein in wheat seedlings (Pascal and Scalla, 1999)

YH: Data curation, Formal Analysis, Software, Writing review and editing