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doi: 10.1254/jphs.fm0070091 381 PredescuDVCretoiuSMCretoiuDPavelescuLASuciuNRaduBMet al

Notably, pharmacological inhibition of either AMPK or autophagy partially restores cell viability but fails to rescue ATP levels, suggesting that hyperactivated mitophagy consumes residual functional mitochondria, thus perpetuating a deleterious feedback loop 32

Contributing factors for T1D pathogenesis, includes genetic factors (HLA, Insulin-VNTR, CTLA-4, PTPN22, AIRE, FoxP3, STAT3, IFIH1, HIP14, ERBB3), epigenetic factors, environmental factors (viruses like rubella and enteroviruses), diet (cereals, cows milk, vitamin-D, and omega-3 fatty acids), gut microbiota, and immunologic factors (Paschou et al., 2018)