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Enhanced Nitric Oxide (NO) Production It has been shown to activate endothelial nitric oxide synthase (eNOS), improving vascular function and integrity

Selhub et al, 1993

Diclofenac and omeprazole based validation of the Nrf2 model Since we are interested in the role of Nrf2 signaling in DILI, we set out to validate the constructed model as based on the general ROS-inducer DEM with two DILI inducing compounds

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This is particularly relevant for patients with pernicious anaemia, where intrinsic factor deficiency prevents adequate oral absorption