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However, a disturbance in the balance between ROS production and cellular antioxidant defenses can lead to an excessive ROS buildup, causing oxidative stress

During adulthood, serum B12 concentrations tend to decline with age, especially in the elderly (Wahlin et al., 2002), probably arising from the gradual decrease in both gastric acidity and intrinsic factor production that occurs with aging (Asselt et al., 1998