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For example, melatonin can not only directly clean ROS but also promote antioxidant enzymes such as GPx and glutathione reductase, thereby indirectly scavenging ROS

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In chronic kidney disease, loss of kidney epithelial cells leads to glomerulosclerosis and tubular atrophy, whereas interstitial inflammation and fibrosis result from an excess of leukocytes and myofibroblasts

nevertheless, they have not yet resulted in statistically meaningful, disease-modifying cognitive outcomes