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Morphine consistently induces long-lasting analgesia (i.e., the reaction time exceeds the values shown in naive saline treated mice)

10.1089/dna.2015.3118 268 WuH.ZengX.YuJ.ShangY.TuM.CheangL

This failure is predominantly attributed to the limitations of animal models in accurately representing human physiology during preclinical evaluations (211)