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Anti-cancer effects of Polyphyllin I: An update in 5 years

doi: 10.1038/nri1226 131 DarnellJEKerrIMStarkGR

moreover, the heightened proliferation and turnover of leukocytes amplify its depletion, since these cells can concentrate vitamin C up to a hundredfold higher than plasma levels, ultimately leading to a substantial reduction in systemic vitamin C availability during sepsis (Oudemans-van Straaten et al., 2014