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To meet this, it seems crucial for any therapeutic approach to consider and effectively apply the three-to-one ratio (Figure 6): three competence-orientated areas of health-related actions, includingfirst and foremostthe prevention of diseases, maintenance of good health status, and promotion of health, followed by one, as a last resort, medicalized therapeutic strategies (as a fourth area of competence-orientated actions) to target specific health conditions, including curing and healing diseases

The benefit is most pronounced for people who are still actively struggling with GI side effects or who are about to escalate to a higher dose

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For researchers, this combination framework is especially useful because it helps dissect whether amylin and incretin signaling act through overlapping or complementary mechanisms