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1 Introduction The liver is the largest solid organ in the human body and is responsible for critical functions such as metabolic regulation, detoxification, bile secretion and immune defence, playing a central role in maintaining homeostasis (Zaefarian et al., 2019)

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The augmentation of the rate-limiting enzymes that facilitate NAD + synthesis, in conjunction with the inhibition of NAD + -degrading enzymes, constitute methodologies for enhancing NAD + levels