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Abstract Significance: The antiulcer peptide, stable gastric pentadecapeptide BPC 157 (previously employed in ulcerative colitis and multiple sclerosis trials, no reported toxicity (LD1 not achieved)), is reviewed, focusing on the particular skin wound therapy, incisional/excisional wound, deep burns, diabetic ulcers, and alkali burns, which may be generalized to the other tissues healing

Research suggests the peptide works through hormetic mechanisms where lower doses may trigger stronger adaptive healing responses in certain tissue types

The peptide also promotes tissue remodeling by regulating matrix metalloproteinases, ensuring damaged collagen is removed while new, healthy collagen is formed

FIGURE 3 FIGURE 4 Basically, closure of fistulas may be a measure of particular agents capacity to cure, at the same time, the skin wound and other corresponding tissues wound (Klicek et al., 2008

GHK-Cu (Glycyl-L-Histidyl-L-Lysine-copper, 402 Da) is a tripeptide-copper complex naturally present in human plasma