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For further investigation, we performed enrichment analysis for HK-2 cells without and with GSH depletion, in the perspective of protein domain (Interpro knowledgebase was used) (Figure 3A)

The diminished function of key antioxidant enzymes and the overproduction of ROS/RNS can disrupt insulin signaling pathways, exacerbating hepatic lipid accumulation

Depress the plunger to inject the medication

Use ice or numbing cream before injection If you are particularly sensitive to needle insertion, apply an ice pack or cold compress to the injection site for 10 to 15 minutes before injecting