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This hypothesis could be explained by a change in the healthy components of the gut ecosystem over time, leading to a lack of training of the IS

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NUPR1 expression overall is not consistently altered in IPF-derived relative to control phBECs, but IPF-derived bronchial epithelia show fewer ciliated cells Given that IPF-derived phBECs were more susceptible to NUPR1 inhibition and scRNA-seq analysis suggested a decrease in NUPR1 expression in IPF compared to control (Fig

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