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Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments

264 All these findings suggest the detrimental role that CCL2/CCR2 signaling pathways play in ischemic stroke

Although none of these cysteines is in the active site, the probability of the modification of one of the cysteines by juglone leading to its inactivation, as seen in the case of Pin-1, Sortase, and RNase P enzymes, seemed a probable mechanism of inhibition