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J., Bredal, I

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Morphologically, no significant abnormalities were seen in the testes and spermatozoa of mice after SNGPX4 KO ( 2.5 GPX5 Glutathione peroxidase 5 (GPX5), an epididymis-specifically expressed selenium-free antioxidant enzyme, was first isolated and identified in the epididymal tissues of mice (Taylor et al., 2013)

Two factors not discussed separately have significant impacts here

Locus rs225014, which confers risk to OA, was associated with the differential methylation of CpG located in the upstream region of DIO2 gene and was correlated with upregulated DIO2 expression in OA 104