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In this article, we'll focus on where it comes from, how it's produced, and why it's become a popular ingredient for wound healing and overall skin rejuvenation, from in-clinic treatments to at-home topical creams and serums

at this point only a few early stage clinical trials are taking place worldwide

[1] Toxicity is extremely rare, though adverse reactions including hypersensitivity can occur, particularly with injectable forms

if the outer annulus fibrosus subsequently ruptures, the nucleus pulposus completely extrudes (non-contained herniation), potentially protruding into the spinal canal or lateral recess, compressing the cauda equina and nerve roots, causing pain or motor dysfunction (Figure 1)