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Dosage and Administration: For Parenteral Use Only , with dosage depending on procedural requirements: Local Anesthesia by Infiltration and Nerve Block: Concentrations of 0.5% to 2% are used based on the desired anesthesia depth

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1 H NMR (500 MHz, DMSO- d 6 ): 1.98 (s, 3H, CH 3 ), 2.902.96 (m, 1H, CH 2 ), 3.203.26 (m, 2H, CH + CH 2 ), 6.79 (d, J = 8.7 Hz, 1H, ArH), 7.32 (dd, J = 2.3, 8.7 Hz, 1H, ArH), 7.57 (d, J = 2.3 Hz, 1H, ArH), 9.19 (br s, 2H, NH 2 ), 9.83 (s, 1H, NH)

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Interruption of the Intratumor CD8:Treg Crosstalk Improves the Efficacy of PD-1 Immunotherapy