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This study confirmed that macrophages secreted NO to adjacent epithelial cells, preventing phospholipid peroxidation in epithelial cells, thereby inhibiting ferroptosis, while NO expression did not affect intracellular GPX4 levels

Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk

In contrast, Tg-I278T Cbs / animals were much less severely affected, with significant differences observed in lean, fat mass, and bone mineral density only in female animals

Meanwhile, the enhancement of glycolysis inhibits the pentose phosphate pathway (PPP), resulting in a decrease in the oxidation rate of G6P and a reduction in the production of reduced glutathione (Tietze, 1969)