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If you have malabsorption syndrome (such as short bowel syndrome, certain bariatric surgery patients, chronic pancreatitis, or celiac disease that severely impairs nutrient uptake), you might need these injections indefinitely to prevent recurrent deficiencies

"Reversal of obesity by targeted ablation of adipose tissue." Nature Medicine 10.6 (2004): 625-632

New washout period for rectal glucocorticoids WADA has now included washout times for glucocorticoids administered by the rectal route

Adequate B12 status helps maintain energy levels even during caloric restriction

For the average adult seeking to maintain healthy levels or boost energy, a single injection once a month is often the standard protocol