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Introduction With the coming of the modern society, chronic sleep loss or sleep deprivation (CSD) has gradually become a prevalent and severe public health problem that affected millions of people worldwide (1, 2)

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Pathologically, when discussing the liver-brain axis, the first thing that clinicians think of is hepatic encephalopathy (HE) due to the liver failure, HE manifests as a wide spectrum of neuropsychiatric abnormalities, including impairment in cognitive/intellectual function, alterations in personality and consciousness, motor activity and coordination, sleep-wake cycle, and finally, coma

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SsSaxA-mediated hydrolysis detoxifies ITCs in S