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However, in addition to the slightly improved performance, the use of HepaRG may be regarded as a superior in vitro metabolic system due to its increased complexity, which allows for the consideration of transmembrane transport processes

Several studies have optimized urea-containing compounds such as SBI-797812 and 1-(2-phenyl-1,3-benzoxazol-6-yl)-3-(pyridin-4-methyl)urea (DS68702229) as potent NAMPT activators, which have been shown to increase NAD + levels in vitro and in vivo, with potential applications in treating metabolic disorders, cardiovascular diseases, and neurodegeneration preclinically 221,222

(2023) 35:633650.e9

doi: 10.3109/09513590.2013.879856 86 HeCWangJLiYZhuKXuZSongYet al

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