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In a recent analysis, 14% of patients with autoimmune diseases permanently discontinued treatment as a result of irAEs, 6 which is only slightly higher than the discontinuation rates observed in clinical trials that excluded patients with autoimmune diseases (3%-8%)

The reclassification does not resolve all scientific questions about these compounds the lack of large-scale human trials remains a real limitation that physicians and patients should take seriously

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Glaucoma is about four times more common in African-Americans than in people of European ancestry, and blindness from glaucoma is about six times more common in African-Americans, Kass says

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