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However, anti-PD-L1 therapy can control the growth of PD-L1-deficient tumors in wild-type mice, suggesting that targeting PD-L1 on host cells specifically MDSCs, rather than tumor cells, may be critical in enhancing anti-PD-1/PD-L1 therapy efficacy [110]

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Synthetic lethality An effect in which two inhibitors or losses of function that, individually, do not produce death in cancer cells, if combined, synergistically induce death