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Apply a generous amount of cream to clean, dry skin

BrentjensRJLatoucheJBSantosEMartiFGongMCLyddaneCet al

doi: 10.1186/s12871-021-01348-z 195 de JongheAvan MunsterBCGoslingsJCKloenPvan ReesCWolviusRet al

Due to the existence of the conjugated system of C = C bonds and carbonyl groups, 4-HNE can provide partial positive charge to the carbon at position three and become efficient electrophiles, allowing it to react with essential biological molecules, including proteins and DNA (107109)