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24 Besides, NADPH acts as the reducing reagent for 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), the rate-limiting enzyme of the mevalonate pathway, which leads to the synthesis of cholesterol and nonsterol isoprenoids

She had gained twelve pounds over two years without any change she could identify

Iron chelation therapy, using agents like deferoxamine, may help prevent iron-driven lipid peroxidation, although its effects on thyroid hormone synthesis must be carefully evaluated (186)

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