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These diseases show a strong association with HLA-B27, but the strength of this association varies among these various forms and among some of the racial/ethnic groups worldwide

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Even though levothyroxine considerably reduces lipid peroxidation, the serum MDA levels never reach the levels seen in healthy individuals (85)

Its bioactivity is primarily attributed to inulina fructan-type polysaccharide (average formula CHO units, -(21) linkages) that constitutes up to 40% of chicory root dry weight (58) and a diverse spectrum of polyphenolic compounds, including chlorogenic acid, chicoric acid, caffeic acid, and flavonoids (5961)

In comparison, OPCs in CILs and RLs upregulate inflammatory IL-6/JAK/STAT and TNF- pathways, and RL OPCs uniquely activate hypoxia and glycolysis pathways, indicative of metabolic reprogramming and emergence of a stress-adapted state