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PMID: 33204339 TheranosticsLXR activation potentiates sorafenib sensitivity in HCC by activating microRNA-378a transcription

They offer protective effects on NASH progression by inhibiting the expression of profibrotic genes that miR-223 targets, including C-X-C motif chemokine ( Cxcl10 ), NOD-, LRRand pyrin domain-containing protein 3 (Nlrp3), transcriptional activator with PDZ-binding (Taz), and insulin-like Growth Factor 1 Receptor ( Igf1r ) in the liver

513 IRE1 activation enhances TLR-mediated pro-inflammatory cytokine production in macrophages and neutrophils, with its regulated IRE1-dependent decay (RIDD) activity stabilizing cytokine mRNA and sustaining a robust inflammatory response in the RA synovium