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(PubMed) Clifton VL, Hodyl NA, Fogarty PA, et al

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Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects

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Research illuminates that sodium propionate (SP)a distinguished SCFA representativewhen administered via encapsulated formulations to maintenance hemodialysis patients, orchestrates immune-metabolic equilibrium through multidimensional pathways: it significantly attenuates pro-inflammatory parameters including CRP, IL-1, and IL-17, while simultaneously upregulating anti-inflammatory mediators such as IL-10, concurrently reducing gut-derived uremic toxin production (IS and PCS), neutralizing oxidative stress markers including malondialdehyde, and rebalancing insulin resistance and iron metabolism perturbations (Marzocco et al., 2018)