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Animal studies further indicate that gut microbiota directly regulate the regenerative potential of the epithelium, particularly by stimulating Lgr5 + stem cells and promoting differentiation of Paneth and goblet cells

However, sustained Akt activation promotes abnormal hepatocyte proliferation and inhibits apoptosis, driving the transformation of MASH to HCC (hepatocellular carcinoma) (156, 157)

Ainsworth, H

5.4.2 Post-transcriptional control mechanisms Post-transcriptional regulation fine-tunes metabolite levels through RNA stability, alternative splicing, and translational control as shown in Figure 7

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