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Autoimmune NZB/NZW F1 mice utilize B cell receptor editing for generating high-affinity anti-dsDNA autoantibodies from low-affinity precursors

declares having received consulting honoraria from Novo Nordisk, Eli Lilly, Merck, Brace Pharma and Eurofarma

Table 1) and improve survival [83]

Each of these drugs has unique properties and are processed by the body in different ways

Therapeutic interventions have been developed and are used clinically, directly targeting epigenetic processes including DNA methylation (e.g., Decitabine) or histone modifications (e.g., Vorinostat), and gene therapies that mimic or counter the effects of ncRNAs are in development