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10.1016/j.ijcard.2018.07.077 44 NeedhamM.MastagliaF

mutation of the gene is associated with some cases of homocystinuria, and methylmalonic aciduria

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However, these in vivo approaches require careful design to balance throughput, ethical considerations, and translational relevance (e.g., dosing regimen, exposure duration), underscoring the need for integrated strategies that leverage both zebrafish and murine models (Xia et al., 2022

To address these concerns, future research must prioritize the development of robust ethical frameworks and regulatory guidelines for AI applications